Alexander Kagansky

Visiting Fellow

Sasha-Kagansky-300x300

PhD in Molecular Biology

kagasha@yahoo.com

Autobiography: Alexander (Sasha) Kagansky is a Visiting Fellow at the University of Stirling, and is setting up an international consortium Biodiversity-to-Biomedicine (Bio2bio). He is also leading the Centre for Genomic and Regenerative Medicine, School of Biomedicine of the Far Eastern Federal University (Vladivostok, UK). Apart from the research in the lab, he is leading the international PhD course for the entrepreneurship in biotechnology, and regularly organizes public engagement of science activities for different target groups including school students, and general public – in different parts of the world, resulting in new collaborations between scientists and artists. 
He is also a member of the executive committee of the Global Young Academy, member of the Young Academy of Scotland, and Mason Institute for Medicine, Life Sciences and the Law, and Innogen institute.

His academic qualifications include PhD (2004), Molecular Biology, National Institutes of Health, Bethesda, USA and Cytology Institute, Saint-Petersburg, Russia; MSc (1998) and BSc (1996) in Biophysics from Saint-Petersburg Polytechnical University, Russia.

Research Interests: Cancer (oesophagus cancer and gliomas) mechanisms, including molecular and cell biology, transcriptomics, epigenetics, genomics, metabolomics, proteomics, diagnostics, and using natural products for the prevention and treatment, functional nutrition, crossover between biodiversity and biomedicine.

Publications

Bio2bio Consortium: Biodiversity, Drug Discovery, and the Future of Global Health – introducing the Biodiversity to Biomedicine Consortium, a Call to Action, Journal of Global Health, 2017 doi: 10.7189/jogh.08.010301

Beesoo R, Bhagooli R, Neergheen-Bhujun VS, Li WW, Kagansky A, Bahorun T. Antibacterial and antibiotic potentiating activities of tropical marine sponge extracts. Physiol C Toxicol Pharmacol. 2017 Apr 6. pii: S1532-0456(17)30078-9. doi: 10.1016/j.cbpc.2017.04.001

Partolina M, Thoms HC, MacLeod K, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun V, Serrels B, Kimura H, Carragher N, Kagansky A. Global Histone Modification Fingerprinting in Human Cells Using Epigenetic Reverse Phase Protein Array. Cell Death Discov. 2017 Mar 6;3:16077. doi: 10.1038/cddiscovery.2016.77

Rybtsov SA, Dumacheva EV, Dumachev DV, Mustafin IG, Kagansky A, Rybtsova NN, Zhdanov RI. Ethical and scientific aspects of human embryonic material research: the Great Britain regulations. Geny I Kletki. 2016 1(11):82-89

Lee HS, Lee NC, Kouprina N, Kim JH, Kagansky A, Bates S, Trepel JB, Pommier Y, Sackett D, Larionov V. Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies. Cancer Res. 2016 Feb 15;76(4):902-11. doi: 10.1158/0008-5472.CAN- 15-1617. Epub 2016 Feb 2

Venkatasubramani AV, McLaughlin K, Blanco GR, Larionov VL, Kagansky A: Pilot RNAi screening using mammalian cell-based system identifies novel putative silencing factors including Kat5/Tip60. AIMS Biophysics, 2015, 2(4): 570-584. doi: 10.3934/biophy.2015.4.570

Zhdanov R, Schirmer, E, Venkatasubramani A, Kerr A, Mandrou E, Blanco GR, Kagansky A: Lipids contribute to epigenetic control via chromatin structure and functions. ScienceOpen Research, 10 (2015). DOI: 10.14293/S2199-1006.1.SOR-LIFE.AUXYTR.v1

Audergon P, Catania S, Kagansky A, Tong P, Pidoux A, Allshire R: Restricted epigenetic inheritance of H3K9 methylation. Science 2015, 2015 Apr 3; 348(6230):132-5. doi: 10.1126/science.1260638

Castonguay E, White S, Kagansky A, St-Cyr DJ, Castillo A, Brugger C, White R, Bonilla C, Spitzer M, Earnshaw W, Schalch T, Ekwall K, Tyers M, Allshire R: Pan-species small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing. Mol Cell Biol. 2015 Feb 15;35(4):662-74. doi: 10.1128/MCB.01102-14. Epub 2014 Dec 8

Bergmann J, Jakubsche J, Martins N, Kagansky A, Nakano M, Kimura H, Kelly D, Turner BM, Masumoto H, Larionov V, Earnshaw WC. Epigenetic engineering: histone mark H3K9 acetylation is compatible with kinetochore structure and function
J Cell Sci. 2012 Jan 15;125(Pt 2):411-21. doi: 10.1242/jcs.090639. Epub 2012 Feb 13

Anderson H, Kagansky A, Wardle J, Rappsilber J, Allshire RC, Whitehall S. Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4. PLoS One. 2010 Oct 18;5(10):e13488. doi: 10.1371/journal.pone.0013488

Bayne E, White S, Kagansky A, Bijos D, Sanchez-Pulido L, Hoe K, Kim D, Park H, Ponting C, Rappsilber J, and Allshire R: Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell 2010; Mar 5; 140(5):666-677

Simmer F, Buscaino A, Kos-Braun IC, Kagansky A, Boukaba A, Urano T, Kerr AR, Allshire R. Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast. EMBO Rep. 2010 Feb;11(2):112-8. doi: 10.1038/embor.2009.273

Djupedal I, Kos-Braun I, Mosher RA, Söderholm N, Simmer F, Hardcastle T, Fender A, Heidrich N, Kagansky A, Bayne E, Wagner EG, Baulcombe DC, Allshire RC, Ekwall K.
EMBO J. 2009 Dec 16;28(24):3832-44

Kagansky A, Folco D, Almeida A, Pidoux A, Boukaba A, Simmer F, Urano T, Hamilton G, and Allshire R: Synthetic heterochromatin bypasses the need for RNAi and centromeric repeats to establish functional centromeres. Science 2009; 324(5935): 1716-9

Pidoux AL, Choi E, Abbott J, Liu X, Kagansky A, Castillo AG, Hamilton GL, Richardson W, Rappsilber J, He X, Allshire R; Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin. Mol Cell. 2009 Feb 13;33(3):299-311

Bayne E, Portoso M, Kagansky A, Kos-Braun I, Urano T, Ekwall K, Alves F, Rappsilber J, Allshire R: Splicing factors facilitate RNAi-directed silencing in fission yeast. Science 2008; 322 (5901): 602-606

Kagansky A, Freeman L, Lukyanov D, Strunnikov A: Histone-tail independent chromatin-binding activity of recombinant cohesin holocomplex. J Biol Chem. 2004; 279(5): 3382-3388

Chervyakova D, Kagansky A, Petukhov M, Lanzov V. [L29M] substitution in the interface of subunit-subunit interactions enhances Escherichia coli RecA protein properties important for its recombinogenic activity. J Mol Biol. 2001 Dec 7;314(4):923-35